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General Hospital


The TRDB Concept

One of the principal products or deliverables, the Trauma-Related Database (TRDB) is a large, relational database warehouse containing clinical, proteomic, cell biology, and gene expression data from our trauma and burns patients and healthy control subject studies. The TRDB provides a browser interface for downloading complete datasets, and more importantly, user-selected data subsets. Data can be downloaded as tables (i.e., relational format) and as binary or text files for use in various data analysis applications.

The program data warehoused in TRDB undergoes a vigorous process of scientific annotation, validation, and curation to insure that the data are of maximum usefulness to the scientific community. While the development of the TRDB as a work product is a work in progress through the end of our funding, access to the curated data in TRDB is available now to our Consortium Members to meet the NIH requirements of timely and responsible release of data. We plan to preserve the TRDB Con (TRDB for Consortium Members) warehouse in perpetuity to serve as a rich source of important clinical, proteomic, and genomic data for the injury research community.

TRDB CON in a Nutshell

The TRBD Con brings together clinical data stored in our production databases as well as genomic and proteomic data obtained from blood and tissues as an integrated data warehouse. In a few steps within the TRDB Con, the investigator can specify or search for patients of interest, choose a set of data to view, export and save as Excel (XLS) or tab-separated text (TXT) format, and/or download microarray image or dChip expression data. Other items that can be downloaded include histology images for tissue derived data, cell phenotype data and computed values.

Clinical data Clinical, physiologic, pathophysiologic, and outcomes data fields are collected to support the analysis and interpretation of the numerous phenotypic, proteomic, and genomic alterations and interactions in patients with severe trauma-induced innate immune and particularly inflammatory processes. Currently, more than 400 trauma, 400 burn, and up to 127 healthy control subjects are represented by numerous time time-independentent variables in tabular, downloadable reports for analysis. In addition, clinical data are available from many time-varying clinical variables that show events measured from time of injury.

Genomic data Gene expression data (Affymetrix® HU133plus v2) from blood leukocyte samples (trauma study) and blood leukocyte samples plus samples of skin, fat, and muscle (burn study) are available in TRDB. The TRDB provides gene expression values based on dChip models and normalization templates developed during Years 3-5 of the Program. When analyzing subsets of gene expression data, we recommend that investigators download the files computed by dChip or by Affymetrix® GCOS software and use them to create their own gene expression data using dChip or other microarray analysis software.

Proteomic and cell biology data From isolated blood monocytes and lymphocytes, data on surface receptors and ligands as well as intra-cellular cytokine and mediator concentrations are available. LC-FTICR mass spectrometry data from isolated PMNs and plasma are also being processed, and will be added to TRDB as these new data are annotated, validated, and curated.

Click on this link for a full description of TRDB Con features and reports. <PDF format>
Click on this link for the TRDB Con Content Statistics Report. <PDF format>

TRDB Demo Version Available to the Public

Better yet, why don’t you run the demo version of TRDB from our website? Our Program has created an on-line demonstration version of the TRDB to provide investigators with a glimpse of the data warehouse capabilities without violating IRB privacy and confidentiality rules. The TRDB Demo represents the current version of the actual TRDB, but does not employ real clinical data. The data in the TRDB Demo are “dummy” datasets for generating the queries and standard reports built into TRDB. Click here to run the TRDB Demo. When you log into the TRDB Demo, use "trdbdemo" for the user name and "trdbdemo" for the password (without the quotes).

How Do I Access the Actual TRDB Con?

The goal of our research program is to disseminate our research data and processes with the scientific community and the general public in a timely and responsible manner consistent with the terms and conditions of the NIH award and our Institutional Review Boards (IRBs). The TRDB Con data are restricted only to the clinical, proteomics, cell biology, and gene expression data that are validated, annotated, and curated. Once these processes have been completed, data are uploaded to TRBD Con for use by any Consortium Member. Consortium member registration is free, and instant membership via creation of your username and password provides early access to our protocols and data as well as access to our Consortium website. From the public home page, you can join the Consortium or log into the Consortium website with your Consortium user name.

To afford the highest level of protection of the confidentiality and privacy of the research subjects, the Massachusetts General Hospital IRB considers the use of the TRDB by any investigator who proposes a research question not directly funded through the program as a secondary use of the data project. As such, Program Administration requires Consortium Members-data requestors to submit a local IRB approval letter for any secondary use of the TRDB data. As the study data in TRDB Con are de-identified data as defined by the Health Insurance Portability and Accountability Act of 1996 (HIPAA), most local IRBs approve the TRDB Con secondary use study through an expedited or exempt review process. Over 50 secondary use projects to access our TRDB data have been approved by various local IRBs throughout the country. Visit the home page of the Consortium website to read more about our policies for access to the TRDB Con data and how to submit your local IRB-approved project to us.

For questions about TRDB Con or our IRB policies, contact the Glue Grant Program Manager.